Publications

2009

Asai-Coakwell, M., French, C.R., Ye, M., Garcha, K., Bigot, K., Perera, A.G., Staehling-Hampton, K., Mema, S.C., Chanda, B., Mushegian, A., Bamforth, S., Doschak, M.R., Li, G., Dobbs, M.B., Giampietro, P.F., Brooks, B.P., Vijayalakshmi, P., Sauvé, Y., Abitbol, M., Sundaresan, P., Heyningen, V.V., Pourquié, O., Underhill, T.M., Waskiewicz, A.J. and Lehmann, O.J. (2009) Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes. Hum. Mol. Genet. 18(6):1110-21

Yamashita A, Krawetz R, and Rancourt DE. (2009) Loss of Discordant Cells during Micr o-Mass Differentiation of Embryonic Stem Cells into the Chondrocyte Lineage. Cell Death Differ 16: 278-86.

Krawetz RJ, Li X, and Rancourt DE. (2009) hES Caught Between a ROCK Inhibitor and a Hard Place. Bioessays 31: 336-343.

Li X, Liu SY, Krawetz RJ, Meng G, and Rancourt DE. (2009) Serum/Feeder-Free Cryopreservation of Single Human Embryonic Stem Cells. Hum Reprod 24: 580-9.

Krawetz RJ, Wu E, Rancourt DE, and Matyas JM. (2009) Osteoblasts Suppress High Bone Turnover Cause by Osteolytic Breast Cancer In Vitro. Exp Cell Res. 315:2333-42.

Krawetz RJ, Cormier JT, Li X, Liu SY, Meng G, Kallos MS and Rancourt DE. Bioreactor expansion of human embryonic stem cells. (resubmitted).

Meng G, Liu S, Li X, Krawetz R, and Rancourt DE. (2009) Derivation of Human Embryonic St em Cell Lines after Blastocyst Microsurgery (submitted).

Li X, Meng G, Liu S, Krawetz R, and Rancourt DE. (2009) Rho Kinase Inhibition Relieves Actin Stress Fiber Formation and Membrane Blebbing in Conventionally Cultured Human Embryonic Stem Cells (submitted).

Meng G, Liu S, Li X, Krawetz R, and Rancourt DE. Extra-cellular Matrix Isolated from Foreskin Fibroblasts Supports Long Term Xeno-Free Human Embryonic Stem Cell Culture (submitted).

Taiani, JT, Krawetz RJ, zur Nieden NI, Wu E, Kallos MS, Matyas, JR and Rancourt DE. Stirred Suspension Bioreactors Promote Embryonic Stem Cell Pluripotency in the Absence of LIF (submitted).

Krawetz RJ, Taiani JT, Greene A, and Rancourt DE. Rho Kinase Inhibition with Y-27632 Reduces Endoderm Lineage Specification during Directed Differentiation of P19 Teratocarcinoma Cells. (in revision).

Yamashita A and Rancourt DE. ES cells form elastic, fibrous and hyaline cartilage in suspension culture and reveals a process of perichondral ossification (in revision).

Welch, I., Cowan, M., Beier, F. and Underhill, T.M. The retinoic acid binding protein Crabp2 is increased in murine models of degenerative joint disease. Arthritis Res. Ther. 11(1):R14

2008

Meng G, Liu S, Krawetz R, Chan M, Chernos J, and Rancourt DE. (2008) A Novel Method for Generating Xeno-Free Human Feeder Cells for Human ES Cell Culture. Stem Cells Dev 17: 413-22.

Li X, Meng G, Krawetz R and Rancourt DE. (2008) The ROCK inhibitor Y-27632 enhances the survival rate of human embryonic stem cells following cryopreservation. Stem Cells Dev 17: 1079-85

G. Wang, H. Uludag. Recent developments in nanoparticle-based drug delivery and targeting systems. Exp. Op. Drug Del. (2008) 5: 499-515.

G. Wang, K. Siggers, S. Zhang, H. Jiang, Z. Xu, R.F. Zernicke, J. Matyas, H. Uludağ. Preparation of BMP-2 containing bovine serum albumin (BSA) nanoparticles stabilized by polymer coating. Pharm. Res. (2008) 25: 2896-2909.

C. Hsu, H. Uludag. Effect of size and topology of DNA molecules on intracellular delivery with no n-viral gene carriers. BMC Biotech. (2008) 8: 23.

B.A. Clements, C.Y.M. Hsu, C. Kucharski, X. Lin, L. Rose, H. Uludağ. Non-viral delivery of basic Fibroblast Growth Factor (bFGF) gene to bone marrow stromal cells. Clin. Orthop. Rel. Res. (2008) in press.

2007

Villemure,I., Cloutier, L., Matyas, J.R. and Duncan, N.A.(2007) Non-uniform strain distribution within rat cartilaginous growth plate under uniaxial compression. Journal of Biomechanics 40:149-56

Gordon, J.A.R., Tye, C.E., Sampaio, A.V., Underhill, T.M., Hunter, G.K., and Goldberg, H.A. (2007) Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro. Bone 41:462-73.

James, C.G., Ulici, V., Tuckermann, J., Underhill, T.M., Beier, F. (2007) Expression profiling of dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development. BMC Genomics Jul 1; 8:205.

zur Nieden NI, Cormier JT, Rancourt DE and Kallos (2007) MS Embryonic Stem Cells Remain Highly Pluripotent Following Long Term Expansion as Aggregates in Suspension Bioreactors. J Biotechnol 129: 421-32.

zur Nieden NI, Price FD, Davis LA, Everitt RE, and Rancourt DE. (2007) Gene profiling on mixed ES cell populations reveals a biphasic role for B-catenin in osteogenic differentiation. Mol Endocrinol 21: 674-85.

Meng GL, zur Nieden NI, Liu SY, Cormier JT, Kallos MS and Rancourt DE. (2007) Properties of murine embryonic stem cells maintained on human foreskin fibroblasts without LIF. Mol Reprod Dev 75: 614-22.

2006

Duncan, N.A. (2006) Cell deformation and micromechanical environment in the intervertebral disc. AAOS Workshop on Intervertebral Disc Degeneration, Journal of Bone and Joint Surgery 88 (Supplement 2): 47-51. 

Hoffman, L.M., Garcha, K., Karamboulas, K., Cowan, M.F. , Drysdale, L.M.Horton, W.A and Underhill, T.M. (2006) BMP action in skeletogenesis involves attenuation of retinoid signaling. Journal of Cell Biology 174(1):101-13.

James, C.G., Woods, A., Underhill, T.M., Beier, F. (2006) The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription. BMC Molecular Biology 19;7:30